protexam Tests
for a long, healthy life
HCU (Heart Check-Up)
Cardiovascular diseases can be seen early on in the form of high blood pressure, increased blood fat levels or shortness of breath! These symptoms often indicate the onset of heart failure or coronary heart disease. The consequences: e.g. heart attack or stroke.
Close by the protexam HCU test You may have a cardiovascular disease. A positive test will diagnose the disease in time, which will significantly improve the success of your treatment.
Referenzen:
- Delles C, et al. Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. J. Hypertens. 2010, 28, 2316–2322.
- Kuznetsova T, Mischak H, Mullen W, Staessen JA. Urinary proteome analysis in hypertensive patients with left ventricular diastolic dysfunction. Eur Heart J. 2012, 33(18):2342-50.
- Campbell RT, et al. The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure. ESC Heart Fail. 2020, 7(4):1595-1604.
KCU (Kidney Check-Up)
In chronic kidney disease, the decline in kidney function progresses slowly over months to years, and the kidney's ability to filter metabolic waste products from the blood gradually decreases.
With the protexam KCU test are already the first changes in the kidneys can be detected early. With appropriate treatment, chronic kidney disease can be avoided.
Referenzen:
- Good DM, et al. Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics 2010, 9(11):2424-37.
- Pontillo C, et al. A urinary proteome-based classifier for the early detection of decline in glomerular filtration. Nephrol Dial Transplant. 2017, 32(9):1510-1516.
- Pontillo C, et al. Prediction of Chronic Kidney Disease Stage 3 by CKD273, a Urinary Proteomic Biomarker. Kidney Int Rep 2017, 2(6):1066-1075.
CRS
(CardioRenal Status)
Diabetics and people with high blood pressure have a three-fold increased risk of sudden cardiac death and around a third are at risk of kidney disease. That is why it is so important to know the risk of these complications as early as possible.
The routine "check-up" with your family doctor or diabetologist often comes too late because only advanced diseases can be diagnosed. For example, the routine test (albuminuria) only shows altered protein values when your kidneys are already irreversibly damaged. Likewise, tests for arteriosclerosis caused by heart failure are only carried out if there is a specific suspicion of the disease. Often, however, the disease is already present by then.
The perfect management: Detecting kidney and cardiovascular diseases 2-5 years before diagnosis with the protexam CRS test!
The protexam CRS test consists of:
- protexam KCU test for the early detection of chronic kidney disease
and
- protexam HCU test for the early detection of an increased risk of heart attack due to arteriosclerosis or heart failure.
Only through timely diagnosis can you significantly improve the success of therapy and avoid both kidney and cardiovascular diseases.
Referenzen:
- Good DM, et al. Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics 2010, 9(11):2424-37.
- Tofte N, et al. Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial. Lancet Diabetes Endocrinol. 2020, 8(4):301-312.
- Delles C. et al. Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. J. Hypertens. 2010, 28, 2316–2322.
- Kuznetsova T, Mischak H, Mullen W, Staessen JA. Urinary proteome analysis in hypertensive patients with left ventricular diastolic dysfunction. Eur Heart J. 2012, 33(18):2342-50.
BCU
(Bladder Check-Up)
Blood in the urine, frequent bladder infections, and increased urinary urgency are not signs of bladder cancer in 90% of cases. protexam BCU test can help to rule out bladder cancer because it can detect tissue changes at an early stage. Ultrasound and urine examinations under a microscope often miss tumors in the early stages.
With the protexam BCU test It is also possible to avoid unnecessary cystoscopies, which carry the risk of injury to the urethra, sphincter or bladder. Early diagnosis and timely treatment can help preserve the bladder.
BSM
(Bladder Status Monitoring)
In the early stages of bladder cancer, ie when the tumor is limited to the surface of the inner bladder wall, treatment with preservation of the bladder is possible. After such a bladder cancer treatment, the cancer can return in 70% of patients.
To check this, 3-month follow-up examinations with cystoscopy are usually carried out. protexam BSM test avoids these unpleasant and risky cystoscopies.
Referenzen:
- Mengual L, et al. A prospective validation of nomograms based on BC-116 and BC-106 urine peptide biomarker panels for bladder cancer diagnostics and monitoring. Br J Cancer 2022, 127(11):2043-2051.
- Frantzi M, et al. Development and Validation of Urine-based Peptide Biomarker Panels for Detecting Bladder Cancer in a Multi-center Study. Clin Cancer Res 2016, 22(16):4077-86.
PCU
(Prostate Check-Up)
An elevated PSA level does not necessarily mean cancer! Almost 80% of PSA results have other causes.*
During the tissue examination (biopsy) there may be complications: e.g. impotence or incontinence. The first step before the biopsy to detect a prostate tumor is the protexam PCU test.
*The results of the ProtecT study show that the routine diagnostic tests used to date to detect prostate cancer are misleading.
For further information visit:
PSM
(Prostata Status Management)
About 45% of patients initially diagnosed with prostate cancer only have a slow-growing form of the cancer. In this case, active surveillance is recommended to treat only patients with aggressive prostate cancer.
With the protexam PSM test aggressive prostate cancer can be detected early and painlessly.
Referenzen:
- Frantzi M, et al. Mass spectrometry-based biomarkers to detect prostate cancer: A multicentric study based on non- invasive urine collection without prior intervention. Cancers (Basel) 2023, 15:1166.
- Frantzi M, et al. Validation of diagnostic nomograms based on CE-MS urinary biomarkers to distinguish clinically significant prostate cancer. World J Urol. 2022, 40(9):2195-2203.
- Frantzi M, et al. CE-MS-based urinary biomarkers to distinguish non-significant from significant prostate cancer. Br J Cancer 2019, 120(12):1120-1128.
xCoV
(severe COVID-19 course)
A COVID-19 disease leads to a severe course in one in five patients. Such a severe (possibly fatal) course can only be prevented in the early stages of the infection, as treatments (e.g. with Paxlovid or monoclonal antibodies) are only effective then. The dangerous thing is that at this point you usually have no symptoms and you only get therapeutic drugs if you are at risk of a severe course.
For further information visit:
Referenzen:
- Wendt R, et al., the CRIT-Cov-U investigators. A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients. EClinicalMedicine 2021, 36:100883.
- Staessen JA, et al., the CRIT-Cov-U investigators. Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a cohort study. Lancet Digit Health 2022, 4(10):e727-e737.
Universal test kit for prevention
Why is the purchase of a universal test kit so important?
Only in the early stages of a disease can it be slowed down or even prevented by appropriate therapy. This is why early detection of the disease is so important. We recommend that you order the protexam universal test kit as a preventative measure so that you can provide your urine sample for a protexam test to be ordered as quickly as possible and send it to us.
For example, you should order the
protexam universal test kit as a preventive measure so that you have the opportunity to send us your urine sample for the protexam xCoV test as quickly as possible if you are diagnosed with COVID-19. This is the only way to quickly predict the course of COVID-19 so that appropriate treatment can be started in good time. Only in the early phase of an infection can suitable treatment prevent a severe course of COVID-19.
Would you like to order a protexam universal test kit as a preventive measure so that you can carry out a protexam xCoV test immediately if you suspect a disease or infection?
When you order the protexam universal test kit, you will be sent a package containing a universal test kit for urine collection. If you then decide to order one of our protexam tests, you have the great time advantage of being able to use the protexam universal test kit already available for urine collection.
The cost of the
protexam universal test kit will of course be credited to you when you order one of our protexam tests. The necessary voucher code is already enclosed with your order.